APOBEC3G-MEDIATED G-TO-A HYPERMUTATION OF THE HIV-1 GENOME: THE MISSING LINK IN ANTIVIRAL MOLECULAR MECHANISMS

APOBEC3G-mediated G-to-A hypermutation of the HIV-1 genome: the missing link in antiviral molecular mechanisms

APOBEC3G (A3G) is a member of the cellular polynucleotide cytidine deaminases, which catalyze the deamination of cytosine (dC) to uracil (dU) in single-stranded DNA.These enzymes potently inhibit the replication of a variety of retroviruses and retrotransposons, including HIV-1.A3G is incorporated into vif-deficient HIV-1 virions and Rattle Blanket

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Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.

Deciphering functional mechanisms of ball stop the Hsp90 chaperone machinery is an important objective in cancer biology aiming to facilitate discovery of targeted anti-cancer therapies.Despite significant advances in understanding structure and function of molecular chaperones, organizing molecular principles that control the relationship between

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Evaluation of Early Warning Scores on In-Hospital Mortality in COVID-19 Patients: A Tertiary Hospital Study from Taiwan

Coronavirus disease 2019 (COVID-19) remains a global pandemic.Early warning scores (EWS) are used to identify potential clinical deterioration, and this study evaluated the ability of the Rapid Emergency Medicine score (REMS), National Early Warning Score (NEWS), and Modified EWS (MEWS) to predict in-hospital mortality in COVID-19 patients.This stu

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«ALMANACH ROYAL» IN THE M. S. VORONTSOV BOOK COLLECTION

During his staying inFranceas a commander of the Russian DRY HAIR SHAMPOO occupation army corps (1815–1818) M.S.Vorontsov, who came from the family of bibliophiles, was eager to complete his library with rare and valuable books.He managed to acquire a great number of rarities including a complete set of a popular year-book «Almanach royal» whic

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